Related Experiment Video
Updated: May 5, 2026
Use of the Scissor-Type Knife During the Peroral Endoscopy Myotomy Procedure for the Treatment of Achalasia
Published on: March 3, 2023
[Peroral endoscopic full and partial-thickness myotomy. A viability study in an animal model]
C D Quiroz-Guadarrama1, M Rojano-Rodríguez2, J J Herrera-Esquivel3
1Residente de Endoscopia Digestiva, Hospital General Dr. Manuel Gea Gonzalez, S.S.A. México, México, D.F., México.
Background:
Peroral endoscopic myotomy has recently been developed and performed on patients with good results.
Aims:
To evaluate the technical feasibility of peroral endoscopic full-thickness and partial thickness myotomy in a porcine model.
Material And Methods:
Eighteen criollo pigs were randomly assigned to 2 groups: group A (partial-thickness myotomy) and group B (full-thickness myotomy). The mucosal defect proximal to the myotomy site was left open. On the seventh postoperative day the pig was euthanized and follow-up surgical exploration was performed. The duration of each procedure, postoperative progression of the animal, complications, and anatomopathologic findings were registered.
Results:
The procedure was viable in all the pigs. The mean surgery duration was 81±35.3min (group A 51.11±11.12, group B 111±22.61; P<.05). The main complication during myotomy was subcutaneous emphysema (16%). The histopathologic study of the group A surgical specimens reported complete circular myotomy in all cases, and complete circular and longitudinal myotomy was reported in 100% of the group B sample.
Conclusions:
The endoscopic myotomy technique is feasible. Endoscopic partial-thickness myotomy was associated with shorter surgery duration and better results during the intraoperative period and the 7-day follow-up.
