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Dissection of Larval Zebrafish Gonadal Tissue
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Mammalian sex determination and gonad development.
Dagmar Wilhelm1, Jennifer X Yang, Paul Thomas
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Current Topics in Developmental Biology
|December 3, 2013
Summary
Gonadogenesis research reveals how common precursors form testes or ovaries. This developmental biology insight aids understanding of congenital disorders of sex development (DSDs) in humans and mice.
Area of Science:
- Developmental biology
- Genetics
- Reproductive medicine
Background:
- Gonadogenesis is the development of testes and ovaries from a common precursor.
- Congenital disorders of sex development (DSDs) affect approximately 1 in 4500 live births.
- Understanding gonadogenesis is crucial for clinical relevance in DSDs.
Purpose of the Study:
- To provide an overview of gonadal morphogenesis and cell lineage specification.
- To update on genetic mechanisms controlling murine gonadogenesis and maintenance.
- To discuss pathological mechanisms of DSDs linked to gene mutations.
Main Methods:
- Comparative analysis of gonadogenesis in mice and humans.
- Review of genetic mechanisms and pathways.
- Exploration of DSDs associated with gene mutations.
Main Results:
- Significant progress in understanding genes controlling sex determination and gonadal development.
- Insights into the elaboration and cross-repression of developmental pathways.
- Identification of conserved genetic mechanisms between mice and humans.
Conclusions:
- Gonadogenesis offers a model for organ development from a bipotential primordium.
- Advances in understanding genetic control of gonadogenesis are improving DSD insights.
- Comparative studies in mice and humans are key to understanding DSD pathology.
Keywords:
Disorders of sexual developmentGenital ridgeGonadogenesisOvarySRYSex determinationSex reversalTestisMore Related Videos
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