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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
Contribution of long noncoding RNAs to autism spectrum disorder risk
Brent Wilkinson1, Daniel B Campbell
1Program in Biological and Biomedical Sciences, University of Southern California, Los Angeles, California, USA; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Abstract:
Accumulating evidence indicates that long noncoding RNAs (lncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few lncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because lncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. We review here the known functions of lncRNAs and the potential contributions of lncRNAs to ASD.
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