Related Experiment Video
Updated: May 5, 2026

Polar Histogram Visualization of Acute Stress Disorder Scale Scores for Comprehensive Clinical Assessment
Published on: December 6, 2024
Preschool anxiety disorders in pediatric primary care: prevalence and comorbidity
Lauren Franz1, Adrian Angold, William Copeland
1Center for Developmental Epidemiology, Duke University Medical Center.
Insights
Anxiety disorders like generalized anxiety disorder, separation anxiety disorder, and social phobia are common in preschoolers. Most anxious preschoolers have only one disorder, but generalized anxiety disorder shows significant comorbidity with other conditions.
Area of Science:
- Child and Adolescent Psychiatry
- Developmental Psychology
- Pediatric Mental Health
Background:
- Anxiety disorders are prevalent in preschool-aged children.
- Understanding comorbidity patterns is crucial for effective intervention.
- Preschoolers represent a critical developmental window for mental health.
Purpose of the Study:
- To determine the prevalence of generalized anxiety disorder, separation anxiety disorder, and social phobia in preschoolers.
- To describe the comorbidity patterns among these anxiety disorders and other conditions in young children.
Main Methods:
- The Duke Preschool Anxiety Study employed a screen-stratified, cross-sectional design.
- Participants included 917 parents of children aged 2-5 years from pediatric primary care settings.
- The Preschool Age Psychiatric Assessment was used to gather data.
Main Results:
- Generalized anxiety disorder, separation anxiety disorder, and social phobia are common in preschool-aged children.
- Approximately 75% of preschoolers with an anxiety disorder had only a single diagnosis.
- Generalized anxiety disorder exhibited the highest comorbidity with separation anxiety disorder, social phobia, disruptive behavior disorders, and depression.
Conclusions:
- Comorbidity patterns in preschoolers differ from older populations, particularly the weaker association between generalized anxiety disorder and depression.
- These findings highlight potential opportunities for early, targeted interventions.
- Interventions could modify the developmental trajectory of anxiety disorders in early childhood.
Objective:
We sought to establish prevalence rates and detail patterns of comorbidity for generalized anxiety disorder, separation anxiety disorder, and social phobia in preschool-aged children.
Method:
The Duke Preschool Anxiety Study, a screen-stratified, cross-sectional study, drew from pediatric primary care and oversampled for children at risk for anxiety. A total of 917 parents of preschool children (aged 2-5 years) completed the Preschool Age Psychiatric Assessment.
Results:
Generalized anxiety disorder, separation anxiety disorder, and social phobia are common in preschool-aged children attending pediatric primary care. Three-fourths of preschoolers with an anxiety disorder only had a single anxiety disorder. Generalized anxiety disorder displayed the greatest degree of comorbidity: with separation anxiety disorder (odds ratio [OR] = 4.1, 95% CI = 2.0-8.5), social phobia (OR = 6.4, 95% CI = 3.1-13.4), disruptive behavior disorders (OR = 5.1, 95% CI = 1.6-15.8), and depression (OR = 3.7, 95% CI = 1.1-12.4).
Conclusions:
The weakness of association between generalized anxiety disorder and depression stands in contrast to substantial associations between these 2 disorders reported in older individuals. Attenuated associations in preschool-aged children could translate into clinical opportunities for targeted early interventions, aimed at modifying the developmental trajectory of anxiety disorders.
Related Concept Videos
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Panic Disorder
Social Anxiety Disorder
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Generalized Anxiety Disorder
Obsessive-Compulsive Disorder

