Preschool irritability: longitudinal associations with psychiatric disorders at age 6 and parental psychopathology
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Updated: May 5, 2026

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
Published on: February 11, 2017
Lea R Dougherty1, Victoria C Smith, Sara J Bufferd
1University of Maryland-College Park.
Insights
Chronic irritability in preschoolers predicts later depression and oppositional defiant disorder. Early detection and intervention for irritability are crucial for addressing early mental health issues.
Area of Science:
- Child and Adolescent Psychiatry
- Developmental Psychology
- Mental Health Research
Background:
- Chronic irritability in youth is gaining attention, but its predictive validity in early childhood is understudied.
- Understanding early irritability is key to identifying and addressing mental health conditions in preschoolers.
Purpose of the Study:
- To examine the associations of chronic irritability with psychiatric disorders and parental psychopathology in preschoolers.
- To assess the predictive validity and clinical significance of chronic irritability in early childhood.
Main Methods:
- A prospective, longitudinal study of 462 preschoolers assessed at 3 and 6 years of age.
- Child psychopathology was assessed using the Preschool Age Psychiatric Assessment (PAPA).
- A dimensional measurement of chronic irritability was derived from PAPA items; parental psychopathology was assessed via diagnostic interview.
Main Results:
- Chronic irritability was concurrently linked to various psychiatric disorders and functional impairment at ages 3 and 6.
- Preschool irritability predicted depression, oppositional defiant disorder, and functional impairment at age 6.
- Irritability was also associated with parental depression and anxiety.
Conclusions:
- Chronic irritability plays a central role in early-emerging mental health problems.
- Findings support the importance of early detection and interventions targeting irritability in preschoolers.
- Results align with studies showing irritability predicts later depression and anxiety in older youth.
Objective:
There is increasing scientific and clinical attention to chronic irritability in youth. However, little is known about the predictive validity and clinical significance of chronic irritability during early childhood. This prospective, longitudinal study examined associations of chronic irritability with psychiatric disorders and parental psychopathology in a large community sample of preschoolers.
Method:
Four hundred sixty-two preschool-age children were assessed at 3 and 6 years of age. Child psychopathology was assessed at baseline (3 years) and follow-up (6 years) using a diagnostic interview, the Preschool Age Psychiatric Assessment, with parents. Items from the Preschool Age Psychiatric Assessment were used to create a dimensional measurement of chronic irritability. Parental psychopathology was assessed with a diagnostic interview at baseline.
Results:
Chronic irritability was concurrently associated with a wide range of psychiatric disorders and functional impairment at 3 and 6 years of age. Irritability at 3 years predicted depression, oppositional defiant disorder, and functional impairment at 6 years after controlling for baseline disorders. Irritability also was associated with parental depression and anxiety.
Conclusions:
Findings underscore the central role of irritability in early-emerging mental health problems. They are consistent with longitudinal studies in older youth indicating that chronic irritability predicts later depression and anxiety and support the importance of early detection and interventions targeting preschool irritability.
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