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Related Experiment Video

Updated: May 5, 2026

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
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Cauda equina involvement in Susac's syndrome.

Andrew M Allmendinger1, Robert M Mallery2, Cynthia M Magro3

  • 1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States.

Journal of the Neurological Sciences
|December 3, 2013
PubMed
Summary

Susac's syndrome, a rare condition, typically presents with encephalopathy, vision loss, and hearing loss. This case highlights a unique presentation involving the cauda equina, expanding the known clinical spectrum of this autoimmune microangiopathy.

Keywords:
Antiendothelial cell antibodiesCauda equina syndromeCorpus callosumEndotheliopathyMRIMicroangiopathyRetinal artery occlusionSusac's syndrome

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Area of Science:

  • Neurology
  • Immunology
  • Vascular Biology

Background:

  • Susac's syndrome is a rare autoimmune microangiopathy.
  • It is characterized by encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss.
  • The classic triad is often incomplete at symptom onset.

Observation:

  • A middle-aged man presented with Susac's syndrome.
  • Unique clinical finding: cauda equina syndrome.
  • Spinal MRI revealed diffuse lumbosacral nerve root enhancement.

Findings:

  • Brain, leptomeninges, and skin biopsies showed pauci-immune endotheliopathy.
  • This pathology aligns with previously described Susac's syndrome cases.
  • The case expands the clinical features of Susac's syndrome.

Implications:

  • This case broadens the understanding of Susac's syndrome clinical manifestations.
  • It clarifies the role of endotheliopathy in this neurological disorder.
  • Endothelial dysfunction is a key target for treating nervous system disorders.