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Updated: May 5, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
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Optimising sample collection for placental research.

G J Burton1, N J Sebire2, L Myatt3

  • 1Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.

Placenta
|December 3, 2013
PubMed
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This summary is machine-generated.

Standardizing human placenta sample collection is crucial for reliable research. This review offers an evidence-based protocol to improve data quality and reproducibility in placental studies.

Area of Science:

  • Reproductive Biology
  • Biotechnology
  • Biobanking

Background:

  • Biobanks are vital for research, but sample integrity is paramount for reliable results.
  • Placental tissue is susceptible to degradation due to delivery stress and delayed collection.
  • Standardized collection protocols enhance sample sharing and enable larger research datasets.

Purpose of the Study:

  • To provide an evidence-based review of factors affecting human placental sample quality.
  • To propose an expert-recommended protocol for optimal placental sample collection.
  • To guide researchers in selecting appropriate collection methods based on study needs.

Main Methods:

  • Expert review of existing literature and best practices.
  • Development of a standardized placental sample collection protocol.
Keywords:
DeliveryGene expressionMetabolismPlacentaSampling

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  • Consideration of specific technique requirements and sample types.
  • Main Results:

    • Identification of critical factors influencing placental sample integrity.
    • A detailed protocol for optimal collection, processing, and storage.
    • Emphasis on the need for standardization to improve data reproducibility.

    Conclusions:

    • Adherence to standardized collection protocols is essential for high-quality placental research.
    • The proposed protocol can be adapted to various research needs and resources.
    • Encouraging international collaboration and sample sharing can significantly advance placental science.