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[Ocular manifestations in Behçet's disease].
H Zeghidi1, D Saadoun2, B Bodaghi1
1Service d'ophtalmologie, DHU vision et handicaps, hôpital de la Pitié-Salpêtrière, université Pierre-et-Marie-Curie, AP-HP, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
La Revue De Medecine Interne
|December 3, 2013
Summary
Behçet's disease commonly causes uveitis, an eye inflammation. Newer treatments like TNF alpha blockers significantly improve vision outcomes for affected patients.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Context:
- Uveitis is a primary ocular manifestation and diagnostic criterion for Behçet's disease.
- Behçet's disease is a chronic, relapsing inflammatory disorder.
- Ocular involvement includes anterior and posterior uveitis, retinal vasculitis, and macular edema.
Purpose:
- To summarize the clinical presentation and management of uveitis in Behçet's disease.
- To highlight risk factors for vision loss in male patients.
- To discuss the impact of novel therapies on visual prognosis.
Summary:
- Anterior uveitis is non-granulomatous, potentially with hypopyon.
- Posterior uveitis can involve vitritis, retinal infiltrates, vasculitis, and macular edema.
- Risk factors for vision loss include male gender, younger age at onset, and poor initial visual acuity.
Impact:
- New therapies, including interferon alpha and TNF alpha blockers, have markedly improved visual outcomes.
- Effective management focuses on rapid inflammation suppression, vision preservation, and sustained remission.
- Understanding Behçet's disease-associated uveitis is crucial for preventing irreversible vision loss.
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