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Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Unusual Pseudomonas corneal ulcers

J H Brinser, E Torczynski

    American Journal of Ophthalmology
    |October 1, 1977
    PubMed

    Insights

    Rare Pseudomonas species, P. acidovorans and P. stutzeri, were identified in corneal ulcers. P. stutzeri

    Area of Science:

    • Ophthalmology
    • Microbiology
    • Infectious Diseases

    Background:

    • Pseudomonas species are known ocular pathogens.
    • Corneal ulcers can lead to severe vision impairment.

    Observation:

    • Two rare Pseudomonas species, P. acidovorans and P. stutzeri, were isolated from corneal ulcers in two separate patients.
    • P. stutzeri was identified for the first time as a cause of corneal disease.

    Findings:

    • P. acidovorans was suspected as the primary pathogen in one case.
    • P. stutzeri infection occurred in a patient with a scarred cornea, suggesting a predisposing factor.
    • Both isolates showed broad antibiotic sensitivity but were resistant to carbenicillin.

    Implications:

    • Highlights the potential of rare Pseudomonas species to cause severe corneal infections.
    • Suggests P. stutzeri as a novel agent in microbial keratitis.
    • Informs antibiotic selection for Pseudomonas-related keratitis, noting resistance to carbenicillin.

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