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Antianginal effects of clonidine
Journal of Cardiovascular Pharmacology
|January 1, 1986
Summary
Clonidine, a central alpha-adrenoceptor agonist, improved exercise tolerance and reduced heart rate-pressure product in patients with stable effort angina pectoris. Both single and chronic doses demonstrated these beneficial cardiovascular effects.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Chronic stable effort angina pectoris poses significant challenges in cardiovascular management.
- Central alpha-adrenoceptor agonists represent a potential therapeutic avenue for managing angina.
Purpose of the Study:
- To evaluate the efficacy of clonidine in patients with chronic stable effort angina pectoris.
- To assess the acute and chronic effects of clonidine on hemodynamic parameters and exercise tolerance.
Main Methods:
- An 18-week randomized, double-blind, two-period crossover study.
- Involved 12 patients with chronic stable effort angina pectoris.
- Clonidine administered as a single dose and chronically (200-400 micrograms twice daily) with washout periods.
Main Results:
- Single-dose clonidine (200 micrograms) decreased rate-pressure product and increased exercise tolerance at 1 and 2 hours post-administration.
- Chronic clonidine administration (200-400 micrograms twice daily) for 3 and 6 weeks resulted in sustained reductions in rate-pressure product and enhanced exercise tolerance.
- No significant adverse events were mentioned in the abstract.
Conclusions:
- Clonidine demonstrates potential as a therapeutic agent for chronic stable effort angina pectoris.
- Both acute and chronic administration of clonidine appear beneficial for improving cardiovascular function and exercise capacity in angina patients.