Related Experiment Video
Updated: May 5, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Polybrominated diphenyl ethers in UK human milk: implications for infant exposure and relationship to external
Mohamed Abou-Elwafa Abdallah1, Stuart Harrad2
1Division of Environmental Health and Risk Management, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom; Department of Analytical Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt.
Abstract:
Fourteen tri-deca polybrominated diphenyl ethers (PBDEs) were investigated in 35 human milk samples from Birmingham, UK. While none of the hepta-nona BDEs (the main components of the octaBDE technical mixture) was above the limit of quantitation (LOQ); BDE-47 (average concentration=3.3ngg(-1) lipid weight (lw)) was quantified in all samples contributing 34-74% to Σtri-hexa BDEs (the principal constituents of the pentaBDE commercial formulation). BDE-209 (the main congener in the decaBDE formulation) was present above the LOQ in 69% of samples (average concentration=0.31ngg(-1) lw). Concentrations of Σtri-hexa BDEs ranged from 0.2 to 26ngg(-1) lw with concentrations of BDE-47>BDE-153>BDE-99. While concentrations of Σtri-hexa BDEs in this study (average=5.95ngg(-1) lw) were at the high end of those reported from other European countries, concentrations of BDE-209 were lower than those reported in human milk from other countries. The average exposure of a UK nursing infant to Σtri-hexa BDEs (35ng (kg bw)(-1)day(-1)) via breast milk exceeded the upper-bound dietary intakes of both UK adults and toddlers. Using a simple one compartment pharmacokinetic model, PBDE intakes of UK adults via inhalation, diet and dust ingestion were converted to predicted body burdens. Predictions compared well with those observed for Σtri-hexa BDEs and BDE-209 in breast milk.
Related Concept Videos
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Development of Human Microbiota
Toxicity Testing in Animals
Pharmacokinetics in Pediatric Patients: Drug Distribution

