Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cardiac Cycle01:13

The Cardiac Cycle

98.3K
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
98.3K
Gallbladder01:17

Gallbladder

2.3K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
2.3K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
Metastasis02:30

Metastasis

6.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.6K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

3.4K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.4K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

2.7K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual arthropathy in previously treated multibacillary leprosy: Inflammatory polyarthritis with neuropathic ankle destruction in an endemic setting.

Tropical doctor·2026
Same author

A Comparative Study of Laparoscopic Versus Robotic Cholecystectomies Based on the Parkland Grading Scale.

Cureus·2024
Same author

Feasibility and safety of robotic-assisted surgical approach in median arcuate ligament syndrome-a systematic review.

Journal of robotic surgery·2024
Same author

Impact of COVID-19 Pandemic on People with Locomotor Disability in North India: A Cross-Sectional Analysis.

Annals of rehabilitation medicine·2024
Same author

Efficacy of Yoga Nidra on Depression, Anxiety, and Insomnia in Frontline COVID-19 Healthcare Workers: A Pilot Randomized Controlled Trial.

International journal of yoga therapy·2023
Same author

Depression and Anxiety among COVID-19 Indian Intensive Care Unit Survivors: A Prospective Observational Study.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023

Related Experiment Video

Updated: Feb 5, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.8K

Cardiac metastasis from gallbladder carcinoma.

Mallikarjun Gunjiganvi1, Ksh Kala Singh, H S Harsha

  • 1Department of Surgery, Regional Institute of Medical Sciences, Imphal, India.

International Journal of Surgery Case Reports
|December 3, 2013
PubMed
Summary
This summary is machine-generated.

Gallbladder carcinoma rarely spreads to the heart, causing cardiac failure. This case highlights the importance of considering cardiac metastasis in patients with a history of gallbladder cancer presenting with heart symptoms.

Keywords:
Cardiac metastasisGallbladder carcinomaMalignant pericardial effusion

More Related Videos

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
08:17

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

11.2K
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.9K

Related Experiment Videos

Last Updated: Feb 5, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.8K
Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells
08:17

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

11.2K
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.9K

Area of Science:

  • Oncology
  • Cardiology
  • Gastroenterology

Background:

  • Primary gallbladder carcinoma is a rare, aggressive cancer with a poor prognosis, often unresectable at diagnosis.
  • Metastasis to the heart from gallbladder cancer is exceptionally rare, with only six cases previously documented.
  • This report details a unique case of gallbladder carcinoma metastasizing to the heart.

Purpose of the Study:

  • To report a rare case of gallbladder carcinoma metastasizing to the heart.
  • To emphasize the diagnostic considerations for cardiac metastasis in gallbladder cancer patients.

Main Methods:

  • A 54-year-old female with a history of gallbladder adenocarcinoma underwent cholecystectomy and chemotherapy.
  • Diagnostic imaging revealed cardiomegaly, myocardial tumor deposits, and malignant pericardial effusion.
  • A pericardial window procedure confirmed metastatic adenocarcinoma via biopsy.

Main Results:

  • The patient presented with dyspnea and chest pain, indicative of cardiac compromise.
  • Imaging confirmed tumor deposits on the myocardium and malignant pericardial effusion.
  • Biopsy confirmed metastatic adenocarcinoma, despite intensive care, the patient succumbed to the disease.

Conclusions:

  • Primary gallbladder adenocarcinoma, while common in the biliary tract, has a dismal prognosis and rare distant metastases.
  • Cardiac metastasis from gallbladder cancer typically presents with heart failure symptoms due to pericardial effusion.
  • Early consideration of cardiac metastasis is crucial for patients with gallbladder cancer experiencing heart failure symptoms.