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Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
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Striking volume intolerance is induced by mimicking arterial baroreflex failure in normal left ventricular function
Kouta Funakoshi1, Kazuya Hosokawa1, Takuya Kishi2
1Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Journal of Cardiac Failure
|December 3, 2013
Summary
Arterial baroreflex failure significantly reduces tolerance to fluid overload in rats, increasing left atrial pressure. Restoring the baroreflex function improved volume tolerance, suggesting its importance in heart failure.
Area of Science:
- Cardiovascular Physiology
- Baroreceptor Function
- Heart Failure Pathophysiology
Background:
- Heart failure with preserved ejection fraction (HFpEF) patients are sensitive to volume overload.
- Arterial baroreflex regulates intravascular volume.
- Investigating baroreflex failure's impact on volume intolerance is crucial.
Purpose of the Study:
- To determine if arterial baroreflex failure causes increased left atrial pressure (LAP) and systemic arterial pressure (AP) during volume loading in rats with normal left ventricular function.
- To assess the role of baroreflex failure in volume intolerance.
Main Methods:
- Used anesthetized Sprague-Dawley rats with isolated carotid sinuses.
- Mimicked arterial baroreflex failure (FAIL) by maintaining constant carotid sinus pressure (CSP) irrespective of AP.
- Infused dextran to determine the relationship between LAP and infused volume (Vi), estimating critical Vi at LAP of 20 mm Hg.
Main Results:
- Arterial baroreflex failure markedly decreased critical Vi (volume tolerance) from 19.4 to 15.6 mL/kg.
- Systemic arterial pressure at critical Vi increased significantly in the failure state.
- An artificial baroreflex system restored normal volume tolerance.
Conclusions:
- Arterial baroreflex failure induces significant volume intolerance even without left ventricular dysfunction.
- Baroreflex dysfunction may contribute to acute heart failure pathogenesis, particularly in HFpEF.
- Restoration of baroreflex function ameliorates volume intolerance.
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