Related Experiment Video

Updated: May 5, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.2K

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

Hemant Kumar1, In-Su Kim, Sandeep Vasant More

  • 1Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, 380-701, Korea. choidk@kku.ac.kr.

Natural Product Reports
|December 3, 2013
PubMed

Insights

Natural compounds activate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, offering protection against chronic diseases. Inhibiting this pathway also shows promise in overcoming drug resistance.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Oxidative stress is a key factor in chronic diseases.
  • The Nrf2/ARE pathway regulates cellular defense against oxidative stress.
  • Dietary phytochemicals can modulate the Nrf2/ARE pathway.

Purpose of the Study:

  • To classify natural compounds that activate the Nrf2/ARE pathway.
  • To explain the mechanisms by which these compounds induce Nrf2.
  • To explore Nrf2 inhibition as a strategy against multi-drug resistance.

Main Methods:

  • Literature review of studies from 2000-2013.
  • Classification of bioactive natural products targeting the Nrf2/ARE pathway.
  • Analysis of molecular mechanisms of Nrf2 induction and inhibition.

Main Results:

  • Identified natural product-derived activators of the Nrf2/ARE pathway.
  • Detailed the molecular mechanisms of Nrf2 activation by these compounds.
  • Highlighted the potential of Nrf2 inhibition in overcoming multi-drug resistance.

Conclusions:

  • Natural compounds activating Nrf2 show therapeutic potential for chronic diseases.
  • Pharmacological inhibition of Nrf2 is a viable strategy to enhance cancer treatment efficacy.
  • Further research into Nrf2 modulators is warranted.

More Related Videos

Preparation of Naringenin Solution for In Vivo Application08:18

Preparation of Naringenin Solution for In Vivo Application

Published on: August 10, 2021

2.9K

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.7K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
6.7K
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
8.6K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
11.9K
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
961