Related Experiment Video
Updated: May 5, 2026

Real-time Visualization and Analysis of Chondrocyte Injury Due to Mechanical Loading in Fully Intact Murine Cartilage Explants
Published on: January 7, 2019
[Transcriptional regulation of chondrogenesis and articular cartilage destruction]
Haruhiko Akiyama1, Kazu Matsumoto
1Department of Orthopedic Surgery, Gifu University, Japan.
Abstract:
In 20th century, cartilage researches were performed by in vitro culture system, and current trend of mouse genetic approaches makes a good progress in the studies of molecular mechanisms underlying chondrogenesis. Sox family and Runt family transcription factors play central roles in chondrogenesis and pathogenesis of osteoarthritis. In this review, we would like to introduce recent progress in understanding of molecular regulation of transcription factors in chondrogenesis and articular cartilage destruction.
Related Concept Videos
Master Transcription Regulators
Growth of Cartilage and Bone Tissue
Bone Formation by Endochondral Ossification
Regulation of Expression at Multiple Steps
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps

