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Common genetic factors influence hand strength, processing speed, and working memory.

Soshiro Ogata¹, Kenji Kato, Chika Honda

¹Department of Health Promotion Science, Osaka University Graduate School of Medicine.

Journal of Epidemiology

|December 3, 2013

Summary

Hand strength is phenotypically linked to processing speed, not working memory. Common genetic factors influence hand strength, processing speed, and working memory, suggesting a shared biological basis for these cognitive functions.

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Area of Science:

Neuroscience
Genetics
Psychology

Background:

Early detection of cognitive decline is crucial to prevent mild cognitive impairment and dementia.
Processing speed and working memory are key cognitive functions affected by decline.
Hand strength offers a simple, cost-effective measure for cognitive decline assessment.

Purpose of the Study:

Investigate phenotypic associations between hand strength, processing speed, and working memory.
Examine the genetic and environmental influences on these associations.

Main Methods:

Utilized monozygotic and dizygotic twin pairs.
Employed generalized estimating equations for phenotypic associations.
Applied structural equation modeling for genetic and environmental structure analysis.

Main Results:

Hand strength showed a phenotypic association with processing speed (digit symbol performance).
No significant phenotypic association was found between hand strength and working memory (digit span performance).
Common genetic factors were identified influencing hand strength, processing speed, and working memory.

Conclusions:

A clear phenotypic link exists between hand strength and processing speed.
Shared genetic factors contribute to hand strength, processing speed, and working memory.