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Updated: May 5, 2026

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications.

C-T Hsiao¹, J-K Choi, S Singh

¹Dynaflow, Inc., 10621-J Iron Bridge Rd., Jessup, MD 20794, USA.

Journal of Fluid Mechanics

|December 3, 2013

Summary

This summary is machine-generated.

This study numerically and analytically investigates microbubble dynamics for targeted cell membrane poration. Findings advance understanding of ultrasound-mediated drug delivery systems using tandem microbubbles.

Keywords:

biological fluid dynamics biomedical flows bubble dynanics

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Area of Science:

Acoustics
Biophysics
Microfluidics

Background:

Ultrasound-mediated delivery utilizes microbubbles for targeted drug and gene delivery.
Tandem microbubbles show potential for directional cell membrane poration in microfluidic systems.

Purpose of the Study:

To elucidate the mechanisms governing the interaction between microbubbles and cell membranes.
To numerically and analytically study the dynamics of single and tandem microbubbles in confined microfluidic environments.

Main Methods:

A 3D boundary element method (BEM) was employed for numerical simulations, modeling complex bubble deformations and jet formation.
Analytical methods considered compressibility and viscous boundary layer effects, complementing the BEM model.
Numerical results were compared with available experimental data.

Main Results:

Energy losses were found to significantly alter bubble dynamics when comparing numerical and analytical approaches with identical initial conditions.
Adjusting initial conditions in the BEM allowed accurate recovery of bubble period and maximum volume, matching infinite medium behavior.
The BEM successfully reproduced the full dynamics of single and tandem bubbles, including large deformations and jet formation.

Conclusions:

The boundary element method serves as a valuable design tool for optimizing tandem-bubble sonoporation experiments.
This research enhances the understanding of microbubble behavior crucial for advancing ultrasound-mediated therapeutic delivery.