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Electroencephalographic findings related with mild cognitive impairment in idiopathic rapid eye movement sleep

Taeko Sasai1, Masato Matsuura, Yuichi Inoue

  • 1Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan ; Yoyogi Sleep Disorder Clinic, Tokyo, Japan ; Department of Somnology, Tokyo Medical University, Tokyo, Japan ; Department of Life Sciences and Bioinformatics, Division of Biomedical Laboratory Sciences, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Sleep
|December 3, 2013
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) is common in idiopathic rapid eye movement sleep behavior disorder (iRBD). EEG slowing during REM sleep and olfactory dysfunction are linked to cognitive decline in iRBD patients.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Cognitive Science

Background:

  • Idiopathic rapid eye movement sleep behavior disorder (iRBD) is associated with α-synucleinopathies.
  • Mild cognitive impairment (MCI) and electroencephalographic (EEG) slowing are frequently observed in iRBD patients.

Purpose of the Study:

  • To investigate the relationship between MCI and physiological markers in patients with iRBD.
  • To identify factors contributing to cognitive impairment in iRBD.

Main Methods:

  • A cross-sectional study was conducted at Yoyogi Sleep Disorder Center.
  • Thirty-one patients with iRBD and 17 age-matched controls participated.
  • Assessments included the Montreal Cognitive Assessment (MoCA), n-polysomnogram (PSG), and Sniffin' Sticks Test.

Main Results:

  • Younger iRBD patients exhibited lower alpha power during wakefulness and reduced MoCA scores compared to controls.
  • MCI was detected in 76.5% of younger iRBD patients.
  • MoCA scores negatively correlated with age, slow-wave sleep proportion, olfactory test scores (TDI), and EEG spectral power.

Conclusions:

  • EEG slowing, particularly during REM sleep, is associated with cognitive decline in iRBD.
  • Olfactory dysfunction also correlates with cognitive impairment in iRBD.
  • These findings highlight potential biomarkers for cognitive changes in iRBD.
Keywords:
ElectroencephalogramLewy body diseaseParkinson diseaseREM sleep behavior disordermild cognitive impairment

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