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Effect of Heparin Administration during Coronary Angiography on Vascular or Peripheral Complications: A Single-Blind

Mohsen Gharakhani1, Farzad Emami

  • 1Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Iranian Journal of Medical Sciences
|December 3, 2013
PubMed

Insights

Administering heparin during coronary angiography did not reduce clot formation or complications. This study found no significant difference in vascular, hemorrhagic, or ischemic events between heparin and placebo groups.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Medicine

Background:

  • Coronary angiography involves contrast agent injection into coronary arteries.
  • The optimal heparin administration strategy during this procedure remains undetermined.
  • This study aimed to evaluate heparin's impact on complications during coronary angiography.

Purpose of the Study:

  • To determine the effect of intravenous heparin administration on vascular, hemorrhagic, and ischemic complications during coronary angiography.
  • To compare outcomes between patients receiving heparin and those receiving a placebo.

Main Methods:

  • A randomized controlled trial involving 500 patients undergoing diagnostic coronary angiography via femoral approach.
  • Patients were assigned to receive either intravenous heparin (2000-3000 units) or a placebo.
  • Exclusion criteria included severe peripheral vascular disease, aortic stenosis, coagulopathy history, and procedures exceeding 30 minutes.

Main Results:

  • Of 482 patients analyzed, heparin administration showed no significant difference in active hemorrhage, groin hematoma, or clot formation compared to placebo.
  • Hemorrhagic complications occurred in 2.9% of the heparin group vs. 1.24% of the placebo group.
  • Vascular and ischemic complications were also not significantly different between the groups.

Conclusions:

  • Heparin administration during coronary angiography did not impact clot formation.
  • The study found no significant effect of heparin on hemorrhagic, ischemic, or vascular complications in patients undergoing coronary angiography.
Abstract

Keywords:
Coronary angiographyHemorrhageHeparinIran

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