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Evaluation of left ventricular function, rotation, twist and untwist in patients with hypertrophic cardiomyopathy

Xue-Wei He1, Ze-Zhou Song

  • 1Department of Ultrasound, Ruian Maternity & Child Care Hospital, Ruian;

Experimental and Clinical Cardiology
|December 3, 2013
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) involves genetic factors and can lead to sudden cardiac death. New imaging techniques help assess left ventricular dysfunction in HCM patients.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition with variable clinical presentations and risks.
  • While conventional echocardiography shows normal systolic function, underlying myocardial dysfunction in HCM is evident.
  • The precise mechanisms of myocardial dysfunction in HCM require further elucidation.

Purpose of the Study:

  • To review the current understanding of hypertrophic cardiomyopathy (HCM).
  • To explore the role of echocardiography and speckle tracking imaging in assessing left ventricular myocardial dysfunction in HCM.
  • To investigate the mechanisms of myocardial twist and untwist in HCM.

Main Methods:

  • Systematic literature search of MEDLINE and PubMed databases.
  • Inclusion of English-language, full-text articles with no date restrictions.
  • Manual search of reference lists for additional relevant publications.

Main Results:

  • Echocardiography is crucial for diagnosing and managing HCM.
  • Speckle tracking imaging offers a novel, noninvasive method to assess left ventricular myocardial dysfunction.
  • Studies confirm the utility of speckle tracking in evaluating HCM.

Conclusions:

  • HCM is an autosomal-dominant disease with significant clinical implications.
  • Advanced echocardiographic techniques like speckle tracking are vital for understanding HCM pathophysiology.
  • Further research into myocardial mechanics is essential for improved HCM patient care.

Keywords:
Hypertrophic cardiomyopathyLeft ventricular rotationTwist

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