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Updated: May 5, 2026
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Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
Published on: June 20, 2018
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Postoperative histological changes in polypose rhinosinusitis
Mohammad Reza Majidi1, Navid Nourizadeh, Kamran Ghafarzadegan
1Otorhinolaryngology-Head & Neck Surgery Department, Qaem Educational Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Summary
Nasal surgery improves nasal mucosa histology by reducing goblet cells in patients with nasal polyposis. This study compared polyp tissue and mucosa before and after surgery to normal controls.
Area of Science:
- Otorhinolaryngology
- Surgical Pathology
- Nasal Mucosa Histology
Background:
- Nasal polyposis is characterized by chronic inflammation and tissue changes in the nasal mucosa.
- Understanding the histological impact of surgical interventions is crucial for managing nasal polyposis.
- Comparing surgical outcomes with normal nasal tissue provides a baseline for evaluating treatment efficacy.
Purpose of the Study:
- To evaluate the histological effect of surgery on nasal mucosa in patients with nasal polyposis.
- To compare the goblet cell percentage in nasal polyps and mucosa before and after surgery with a control group.
Main Methods:
- A case-control study involving 20 patients undergoing sinus endoscopy for nasal polyposis.
- Tissue specimens (polyps and inferior conchae mucosa) were collected pre- and post-surgery from cases, and mucosa from controls.
- Quantification of goblet cells as a percentage of epithelial cells was performed for all specimens.
Main Results:
- Goblet cell percentage was significantly lower in polyps (15.7%) compared to preoperative nasal mucosa (39.86%) and postoperative mucosa (13.3%).
- Preoperative nasal mucosa in the case group (39.86%) showed a significantly higher goblet cell percentage than the control group (4.9%).
- Postoperative nasal mucosa also exhibited a significantly lower goblet cell percentage than preoperative mucosa.
Conclusions:
- Surgical intervention for nasal polyposis leads to histological improvement, evidenced by reduced goblet cell percentages.
- Surgery offers benefits beyond just airway opening, including favorable changes in nasal mucosa histology.
- The findings suggest that surgical treatment positively impacts the cellular composition of the nasal mucosa in polyposis patients.
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