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Related Experiment Videos

[Plasma fibronectin in the aged].

E J Menzel, A Dunky

    Zeitschrift Fur Gerontologie
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Plasma fibronectin shows reduced gelatin binding and opsonizing activity in very old individuals, impacting clearance of tissue fragments. Despite higher concentrations, other functions remain largely unaffected.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Gerontology

    Context:

    • Aging is associated with altered protein function.
    • Plasma fibronectin plays a crucial role in immune response and tissue repair.
    • Very old individuals (86-95 years) present a unique model for studying age-related changes.

    Purpose:

    • To investigate the biochemical and functional characteristics of plasma fibronectin in very old humans.
    • To assess the impact of aging on fibronectin's binding affinity and opsonizing capacity.
    • To compare fibronectin's behavior with acute phase proteins and complement components in the elderly.

    Summary:

    • Plasma fibronectin in very old individuals (86-95 years) maintained its molecular weight but exhibited significantly reduced affinity for gelatin.

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  • This reduction in binding capacity impairs the opsonizing activity of fibronectin, leading to slower clearance of connective tissue fragments from circulation.
  • Elevated plasma fibronectin concentration in this age group did not correlate with general irregularities in acute phase proteins or unchanged hemolytic activity of C1 and C3 complement components.

    • Impact:

    • Findings suggest a functional decline in fibronectin's immune-mediated clearance mechanisms in extreme old age.
    • This age-related impairment may influence the body's response to injury and trauma in the elderly.
    • Highlights the complexity of aging, where specific protein functions decline despite potentially compensatory increases in concentration.