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Updated: May 5, 2026

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
Published on: July 31, 2017
Children with autism spectrum disorder and epilepsy
Insights
Autism spectrum disorder (ASD) is a neurodevelopmental disability. This review covers epilepsy and EEG findings in ASD, exploring controversial links and treatment options.
Area of Science:
- Neuroscience
- Developmental Pediatrics
- Clinical Neurology
Background:
- Autism spectrum disorder (ASD) is a neurodevelopmental disability impacting social communication and behavior.
- A significant comorbidity exists between ASD and epilepsy, with up to one-third of individuals experiencing seizures.
- The precise relationship between autism and epilepsy remains a subject of ongoing research and debate.
Purpose of the Study:
- To review the types of seizures observed in children and adolescents with ASD.
- To discuss electroencephalography (EEG) findings in the context of ASD and epilepsy.
- To outline current treatment strategies for seizures in individuals with ASD.
Main Methods:
- Literature review of studies on autism spectrum disorder, epilepsy, and EEG abnormalities.
- Analysis of seizure types, EEG patterns, and treatment approaches.
- Examination of associated syndromes linking autism phenotype and epilepsy.
Main Results:
- ASD is characterized by social-communication deficits and restricted behaviors.
- Epilepsy and epileptiform EEG abnormalities are more prevalent in children with ASD.
- Various seizure types and EEG findings are associated with ASD.
Conclusions:
- The co-occurrence of epilepsy in ASD warrants further investigation into underlying mechanisms.
- Understanding seizure types and EEG findings is crucial for managing ASD.
- Comprehensive management strategies are needed for individuals with both ASD and epilepsy.
Abstract:
Autism spectrum disorder (ASD) is a biologically based neurodevelopmental disability characterized by qualitative and persistent deficits in social communication and social interaction and by the presence of restricted, repetitive, and stereotyped patterns of behavior. Symptoms must be present in early childhood and they must limit and impair everyday functioning. There is an increased prevalence of epilepsy and/or epileptiform electroencephalography (EEG) abnormalities in children with ASD. It is estimated that approximately one-third of children and adolescents with ASD experience seizures, but the relationship between epilepsy and autism is controversial. This article reviews the types of seizures associated with ASD, the EEG findings, and current treatment strategies. The article also describes syndromes associated with the autism phenotype and epilepsy.
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