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Updated: May 5, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Hypertrophic cardiomyopathy

Kim Subasic1

  • 1Department of Nursing, University of Scranton, Linden Street, Scranton, PA 18510, USA.

The Nursing Clinics of North America
|December 4, 2013
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a genetic heart condition affecting 1 in 500 people, potentially leading to sudden cardiac death. Early diagnosis and personalized treatment are crucial due to its often silent nature and varied symptoms.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is an autosomal dominant cardiovascular disorder.
  • It affects approximately 1 in 500 individuals.
  • HCM carries a significant risk of sudden cardiac death.

Purpose of the Study:

  • To provide a comprehensive overview of hypertrophic cardiomyopathy.
  • To discuss pathophysiology, symptoms, complications, diagnostics, and treatment.
  • To highlight the challenges in diagnosing silently presenting HCM.

Main Methods:

  • Literature review of pathophysiology, clinical presentation, and management strategies.
  • Discussion of diagnostic modalities for HCM.
  • Overview of current and emerging therapeutic approaches.

Main Results:

  • HCM presents with diverse clinical manifestations, often silently.
  • Diagnostic challenges arise from its variable and subtle presentation.
  • Individualized therapy is essential for effective management.

Conclusions:

  • Effective management of HCM requires a thorough understanding of its varied presentation.
  • Prompt identification and tailored treatment strategies are key to improving outcomes.
  • Personalized therapeutic approaches are necessary for patients with HCM.

Keywords:
Autosomal dominantHypertrophic cardiomyopathySudden cardiac death

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