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Related Experiment Video

Updated: May 5, 2026

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
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Reprint of: Mapping connectivity in the developing brain.

Emily L Dennis1, Paul M Thompson1

  • 1Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles Young Drive South, Suite 225, Los Angeles, CA 90095-7334, USA.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|December 4, 2013
PubMed
Summary

This review explores brain connectivity development in typical and neurodevelopmental disorders, highlighting insights into the human connectome and developmental brain disorders.

Keywords:
22q11.2 DSADHDAutismBrain connectivityDTIDevelopmentFragile XHARDITurner syndromeWilliams syndromers-fMRI

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Brain Imaging

Background:

  • Research on structural and functional brain connectivity has advanced understanding of human brain development.
  • Numerous methods exist for assessing brain connectivity, each with unique strengths.

Purpose of the Study:

  • To review the development of structural and functional brain connectivity.
  • To examine connectivity in typically developing individuals and those with neurodevelopmental disorders.
  • To highlight recent findings in autism, Fragile X, 22q11.2 deletion syndrome, Williams syndrome, Turner syndrome, and ADHD.

Main Methods:

  • Review of existing research on brain connectivity development.
  • Focus on studies involving both typically developing subjects and those with neurodevelopmental disorders.

Main Results:

  • Significant progress has been made in understanding the developmental trajectory of the human connectome.
  • Insights gained into characteristic features of brain development and biological processes in developmental disorders.
  • Common themes identified include hemispheric specialization and sex differences.

Conclusions:

  • The study of brain connectivity offers valuable insights into typical and disordered brain development.
  • Future directions include integrating imaging and genetics and exploring structural-functional connectivity relationships.