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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

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Published on: February 22, 2019

Development of immunization trials against Pasteurella multocida.

Tarek A Ahmad¹, Samar S Rammah², Salah A Sheweita²

¹Scientific Support and Projects Section, Bibliotheca Alexandrina, Alexandria, Egypt.

|December 4, 2013

Summary

This review examines Pasteurella multocida vaccines for farm animals, highlighting challenges with antibiotic resistance and exploring various vaccine development trials since the 1950s. It details the benefits and drawbacks of different vaccine approaches to control pasteurellosis.

Keywords:

Immunotherapy Pasteurella multocida Pasteurellosis Vaccine

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Area of Science:

Veterinary Medicine
Microbiology
Immunology

Background:

Pasteurellosis, caused by Pasteurella multocida, is a significant respiratory disease in valuable livestock like poultry, rabbits, cattle, goats, and pigs.
The disease results in substantial economic losses, with symptoms ranging from local infections to fatal septicemia.
Antibiotic resistance and toxicity limit the efficacy and safety of chemotherapeutic treatments for Pasteurella infections.

Purpose of the Study:

To review and classify vaccine development trials for Pasteurella multocida conducted since the 1950s.
To document the evolution of immunization strategies against pasteurellosis in farm animals.
To critically analyze the benefits and drawbacks of various vaccine formulations and approaches.

Main Methods:

Comprehensive literature search for studies on Pasteurella multocida vaccine development.
Classification of vaccine trials based on formulation and methodology.
Comparative analysis of efficacy, safety, and limitations of different vaccine groups.

Main Results:

Identified numerous vaccine trials with varying success rates and methodologies.
Highlighted the persistent challenges in developing universally effective and safe vaccines against Pasteurella multocida.
Documented the advantages and disadvantages associated with different vaccine types, including live, inactivated, and subunit vaccines.

Conclusions:

Vaccination remains the most potent preventive measure against pasteurellosis, despite challenges.
Continued research and development are crucial for overcoming antibiotic resistance and improving vaccine efficacy.
A thorough understanding of past vaccine trials is essential for future advancements in controlling Pasteurella multocida infections in livestock.