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Related Experiment Video

Updated: May 5, 2026

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The complexity of globus: a multidisciplinary perspective.

Margot Selleslagh1, Lukas van Oudenhove2, Ans Pauwels2

  • 1Department of Neurosciences, ExpORL and Translational Research Center for Gastrointestinal Disorders (TARGID), Herestraat 49 (PO 701), 3000 Leuven, Belgium.

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|December 4, 2013
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Summary
This summary is machine-generated.

Globus sensation, a common yet poorly understood condition, likely stems from multiple interacting factors, not a single cause. A multifactorial approach is crucial for accurate diagnosis and effective treatment of globus symptoms.

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Area of Science:

  • Gastroenterology
  • Otorhinolaryngology
  • Psychiatry/Psychosomatic Medicine

Background:

  • Globus sensation is a prevalent condition across multiple medical specialties.
  • Despite numerous hypotheses, the exact etiology of globus remains incompletely understood.
  • Existing diagnostic criteria may not encompass the full spectrum of globus presentation.

Purpose of the Study:

  • To review and critically evaluate the existing literature on globus etiology.
  • To discuss the quality of evidence supporting various proposed causes of globus.
  • To advocate for a comprehensive, multifactorial understanding of globus pathogenesis.

Main Methods:

  • Comprehensive literature review of studies on globus sensation.
  • Analysis of evidence quality regarding associated factors.
  • Synthesis of findings to address gaps in current understanding.

Main Results:

  • Globus is linked to oropharyngeal lesions, sphincter dysfunction, esophageal disorders, GERD, and psychosocial factors.
  • Evidence is often contradictory, leading to inconclusive findings on globus etiology.
  • Current diagnostic criteria (Rome III) are limited, particularly for functional globus.

Conclusions:

  • Globus likely results from a combination of interacting factors rather than a single cause.
  • The symptomatology of globus may be broader than currently recognized.
  • A multidisciplinary, multifactorial approach is essential for managing globus patients effectively.