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Updated: Feb 19, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
Novel putative mechanisms to link circadian clocks to healthy aging
Aurel Popa-Wagner1, Bogdan Catalin, Ana-Maria Buga
1Department of Psychiatry and Psychotherapy, University Rostock Medical School, Rostock, Germany, aurel.popa-wagner@med.uni-rostock.de.
Abstract:
The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting. Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process. Our aim is to give an overview of how the central clock in the hypothalamus and peripheral clocks relate to aging and metabolic disorders, including hyperlipidemia and hyperglycemia. In particular, we unravel novel putative mechanisms to link circadian clocks to healthy aging. This review may lead to the design of large-scale interventions to help people stay healthy as they age by adjusting daily activities, such as feeding behavior, and or adaptation to age-related changes in individual circadian rhythms.
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