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Growth hormone neurosecretory dysfunction.

B B Bercu, F B Diamond

Clinics in Endocrinology and Metabolism

|August 1, 1986

Summary

This summary is machine-generated.

Disorders in the neuroregulation of growth hormone (GH) secretion, potentially GH neurosecretory dysfunction (GHND), may cause short stature. Disruptions in neurotransmitter-neurohormonal pathways are implicated in poor growth velocity.

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Area of Science:

Neuroendocrinology
Pediatric Endocrinology
Neuroscience

Background:

Understanding clinical disorders of growth hormone (GH) secretion relies on the complex central nervous system (CNS)-hypothalamic-pituitary axis.
Evidence from animal and human studies supports neurosecretory control over GH secretion, involving neurohormones, neurotransmitters, and neuropeptides.

Purpose of the Study:

To explore the hypothesis that a disorder in neurosecretion, termed GH neurosecretory dysfunction (GHND), causes short stature.
To investigate the role of disrupted neuroregulatory control in GH secretion.

Main Methods:

Review of anatomical, physiological, and pharmacological evidence for neurosecretory control of GH secretion.
Observation of defects in neuroregulatory control of GH secretion in CNS-irradiated subjects.

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Main Results:

CNS irradiation in humans and animals revealed defects in the neuroregulatory control of GH secretion.
This observation supports the hypothesis of GH neurosecretory dysfunction (GHND) as a cause of short stature.

Conclusions:

A disruption in the neurotransmitter-neurohormonal functional pathway is speculated to modify GH secretion.
This disruption may manifest as poor growth velocity and short stature in children with heterogeneous conditions.