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Related Experiment Videos

Irradiation-induced growth failure.

S M Shalet

    Clinics in Endocrinology and Metabolism
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Radiation-induced growth hormone deficiency is common in children treated for brain tumors or ALL. Pharmacological tests like the insulin tolerance test are useful for diagnosis, and growth hormone-releasing factor may be an alternative treatment.

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    Use of a GH receptor antagonist (GHRA) to explore the relationship between GH and IGF-I in adults with severe GH deficiency (GHD).

    Clinical endocrinology·2008

    Area of Science:

    • Pediatric Endocrinology
    • Oncology
    • Radiation Oncology

    Background:

    • Short stature is a common complication in children treated for brain tumors and acute lymphoblastic leukemia (ALL).
    • Potential causes include spinal irradiation, malnutrition, recurrent disease, chemotherapy, precocious puberty, and radiation-induced growth hormone (GH) deficiency.
    • Radiation damage to the hypothalamic-pituitary axis often affects GH secretion first, potentially leading to panhypopituitarism with higher doses.

    Purpose of the Study:

    • To evaluate the utility of pharmacological tests in diagnosing radiation-induced GH deficiency in children.
    • To explore the potential of growth hormone-releasing factor (GRF) as an alternative treatment.

    Main Methods:

    • Assessment of GH secretion using pharmacological tests, particularly the insulin tolerance test (ITT).

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  • Evaluation of the radiosensitivity of the hypothalamus versus the pituitary gland.
  • Consideration of synthetic GRF for therapeutic intervention.

    • Main Results:

    • GH deficiency is a frequent consequence of radiation therapy for pediatric central nervous system tumors and ALL.
    • The hypothalamus is more radiosensitive than the pituitary, often leading to reduced endogenous GRF.
    • The ITT is a sensitive test for detecting radiation-induced GH deficiency due to the vulnerability of GH response to hypoglycemia.
    • GH therapy is not associated with an increased risk of tumor recurrence or leukemia relapse.

    Conclusions:

    • Pharmacological testing, especially ITT, is crucial for diagnosing radiation-induced GH deficiency in children.
    • Hypothalamic damage leading to GRF deficiency is a key mechanism.
    • Synthetic GRF presents a potential alternative treatment to GH therapy for these patients.
    • GH therapy is safe and does not increase the risk of cancer recurrence.