Related Experiment Video

Updated: May 5, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

16.5K

Cancer stem cells in brain tumors and their lineage hierarchy

Doo-Sik Kong1

  • 1Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

International Journal of Stem Cells
|December 4, 2013
PubMed

Insights

Malignant glioma remains difficult to treat due to tumor heterogeneity. Cancer stem cells, a subpopulation of tumor cells, are key to understanding and potentially overcoming this chemo-resistance.

Area of Science:

  • Oncology
  • Cancer Biology

Background:

  • Malignant glioma prognosis remains poor despite targeted therapies.
  • Tumor heterogeneity contributes to chemo-resistance in malignant glioma.

Purpose of the Study:

  • To review and discuss the concept of cancer stem cells.
  • To explore cancer stem cells as potential therapeutic targets for malignant glioma.

Main Methods:

  • Literature review of cancer stem cell research.
  • Discussion of tumor heterogeneity and chemo-resistance mechanisms.

Main Results:

  • Cancer stem cells are a distinct subpopulation within tumors.
  • Cancer stem cells are implicated in malignant glioma chemo-resistance.

Conclusions:

  • Cancer stem cells represent a promising therapeutic target for malignant glioma.
  • Further research into cancer stem cells is crucial for improving treatment outcomes.
Keywords:
Cancer stem cellCell of originLineage hierarchy

More Related Videos

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

28.6K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.2K

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.3K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.0K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.8K
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
3.4K
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
12.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K