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Anal involvement in pemphigus vularis.

Somayeh Khezri1, Hamid-Reza Mahmoudi, Seyedeh Nina Masoom

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Summary
This summary is machine-generated.

Pemphigus vulgaris (PV) frequently affects the anal mucosa, with over 27% of patients showing involvement. Routine anal examinations are recommended, even for asymptomatic individuals, due to its correlation with disease severity.

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Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Mucosal Manifestations

Background:

  • Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting skin and mucosa.
  • Anal mucosal involvement in PV is not well-characterized.

Purpose of the Study:

  • To determine the frequency and clinical features of anal area involvement in newly diagnosed PV patients.

Main Methods:

  • 168 consecutive newly diagnosed PV patients were assessed.
  • Data collected included anal symptoms/signs, other affected body sites, and disease severity.

Main Results:

  • 27.9% of patients (47/168) had anal involvement.
  • Anal involvement correlated with lesions in ophthalmic, nasal, and genital mucosa, and with oral severity.
  • Constipation and pain on defecation were common symptoms; erosion was the most frequent sign.

Conclusions:

  • Anal involvement in PV is more common than previously thought.
  • Routine anal examination is advised for PV patients, including those without symptoms.
  • Anal involvement may indicate overall PV severity.