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Published on: August 13, 2015
Nimesulide induced histopathological changes in the vas deferens of mice
Thotakura Balaji1, Manickam Subramanian, Vaithianathan Gnanasundaram
1Professor, Department of Anatomy, Chettinad Hospital & Research Institute , Kelambakam - 603 103, Tamil nadu, India .
Aim:
Nimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and the available information is scanty. AIMs and Objectives: The present study aims to investigate the adverse effects of nimesulide in the vas deferens thereby indirectly assess the role of COX-2 in male reproductive tract.
Material And Methods:
Nimesulide was administered orally and the animals were maintained for different time periods prior to sacrifice.
Results:
The vas deferens of nimesulide treated mice showed extensive histopathological changes such as vacoulation and exfoliation of cells in the epithelial layer.
Conclusion:
Nimesulide administration leads to cytotoxic effects suggestive of apoptosis in the vas deferens of mice.
