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Skin cellular retinoid-binding proteins and retinoid-responsive dermatoses
Dermatologica
|January 1, 1986
Summary
Cellular retinoic acid-binding protein (CRABP) is elevated in various skin conditions, unlike cellular retinol-binding protein (CRBP). Higher CRABP levels may predict better response to retinoid therapy, suggesting CRABP
Area of Science:
- Dermatology
- Biochemistry
- Molecular Biology
Background:
- Cellular retinoic acid-binding protein (CRABP) is notably increased in psoriatic plaques.
- Cellular retinol-binding protein (CRBP) levels remain unchanged in psoriatic plaques compared to normal skin.
Purpose of the Study:
- To investigate CRABP and CRBP levels across a spectrum of dermatoses.
- To explore the potential role of CRABP as a skin receptor for synthetic retinoids.
- To assess the utility of CRABP analysis in monitoring retinoid therapy.
Main Methods:
- Analysis of CRABP and CRBP levels in various skin conditions.
- Comparison of protein levels in lesional and non-lesional skin.
- Observation of CRABP and CRBP changes following systemic etretin administration.
Main Results:
- CRBP levels showed minimal variation across dermatoses.
- CRABP levels were elevated in psoriatic plaques, lamellar ichthyosis, Darier disease, pityriasis rubra pilaris, and keratosis pilaris.
- Systemic etretin treatment increased CRABP levels but not CRBP levels.
Conclusions:
- Elevated CRABP in skin lesions may indicate increased sensitivity to specific synthetic retinoids.
- CRABP is suggested to function as a receptor for synthetic retinoids in the skin.
- CRABP level monitoring could be valuable for optimizing retinoid treatment.