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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontitis and type II diabetes: a two-way relationship
Brian Chee1, Boram Park, P Mark Bartold
1Department of Dentistry, University of Adelaide, Adelaide, South Australia, Australia.
International Journal of Evidence-Based Healthcare
|December 5, 2013
Summary
Diabetes and periodontitis have a bidirectional relationship, where each condition worsens the other. Managing diabetes can moderately improve glycemic control, highlighting the importance of addressing both conditions.
Area of Science:
- Oral health
- Endocrinology
- Immunology
Background:
- A long-suspected association exists between diabetes and periodontitis.
- Recent evidence suggests this relationship is bidirectional, with each condition influencing the other.
Purpose of the Study:
- To review the bidirectional relationship between diabetes and periodontitis.
- To explore the influence of each condition on the other.
Main Methods:
- A narrative review was conducted.
- Literature search performed using EMBASE and MEDLINE (PubMed).
- Reference lists of selected papers were also scanned.
Main Results:
- Diabetes is a risk and modifying factor for periodontitis, especially when uncontrolled.
- Mechanisms include adipokine-mediated inflammation, neutrophil dysfunction, and AGE-RAGE interaction.
- Periodontitis may affect diabetes and its complications; periodontal therapy can moderately improve glycemic control.
Conclusions:
- Diabetes and periodontitis are intricately interrelated.
- Each condition influences the clinical features of the other.
- Further research into the mechanisms and therapeutic implications is warranted.
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