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Updated: May 5, 2026

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
Cerebellar abscess caused by Listeria monocytogenes in a liver transplant patient
N Choudhury1, A B Khan, I Tzvetanov
1Division of Transplantation, Department of Surgery, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, USA.
Abstract:
Brain abscesses are a rare but serious complication and have been documented in transplant recipients. Aspergillus is by far the most frequent etiology of post-transplant brain abscesses. Bacteria, apart from Nocardia, have a low association with brain abscesses in transplant recipients. We report herein the case of a 52-year-old man who had undergone orthotopic liver transplantation (OLT) for end-stage liver disease and hepatocellular carcinoma secondary to chronic hepatitis, and who developed a cerebellar abscess (CA) from Listeria monocytogenes. Three months after transplantation, he presented with a 1-week history of headache and vomiting. Computed tomography scan of the brain revealed a space-occupying lesion in the right cerebellum, which was further confirmed by magnetic resonance imaging. Emergency surgery was planned because of pressure effect on the surrounding structures. The patient recovered smoothly from the surgery. To our knowledge, no reports of Listeria CA following OLT have been published in the English literature. This case shows that, although extremely rare, L. monocytogenes may cause CA in liver transplant recipients, and clinicians should be aware of this, so that prompt diagnosis and treatment can be instituted before serious brain damage can occur.
Insights
Listeria monocytogenes, a rare cause of brain abscesses, can affect liver transplant recipients. This case highlights the importance of considering this pathogen for prompt diagnosis and treatment to prevent severe neurological damage.
Area of Science:
- Infectious Diseases
- Neurosurgery
- Transplantation Medicine
Background:
- Brain abscesses are infrequent but severe complications in transplant recipients.
- Aspergillus is the predominant cause of post-transplant brain abscesses.
- Bacterial involvement, excluding Nocardia, is uncommon in transplant-associated brain abscesses.
Observation:
- A 52-year-old male liver transplant recipient developed a cerebellar abscess.
- The abscess was caused by Listeria monocytogenes, an unusual pathogen in this context.
- Symptoms included headache and vomiting three months post-transplantation.
Findings:
- Cerebellar abscess (CA) diagnosed via CT and MRI.
- Emergency surgery was performed due to mass effect.
- The patient experienced an uncomplicated surgical recovery.
Implications:
- This case represents the first reported instance of Listeria monocytogenes causing a cerebellar abscess after orthotopic liver transplantation (OLT).
- Clinicians must maintain awareness of L. monocytogenes as a potential, albeit rare, cause of CA in OLT patients.
- Prompt recognition and management are crucial to avert significant neurological sequelae.
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