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Thyroxine-binding prealbumin, overnutrition and apolipoprotein A1
Human Nutrition. Clinical Nutrition
|September 1, 1986
Summary
Thyroxine-binding prealbumin (TBPA) does not effectively distinguish between healthy individuals with low or high energy intake. This study found TBPA levels are not a reliable indicator of overnutrition in the general population.
Area of Science:
- Biochemistry
- Nutritional Science
- Clinical Chemistry
Background:
- Thyroxine-binding prealbumin (TBPA) is a potential biomarker for subclinical malnutrition.
- Its sensitivity to nutritional intake suggests possible use in assessing energy consumption levels.
Purpose of the Study:
- To investigate if TBPA levels can differentiate healthy individuals based on energy intake.
- To determine if TBPA can serve as an index for overnutrition in a healthy working population.
Main Methods:
- Measured circulating TBPA levels in three groups of healthy French adults with varying energy intakes.
- Analyzed correlations between TBPA, nutrient intake, and general nutritional status parameters.
Main Results:
- TBPA levels did not significantly differ between groups with low, medium, or high energy intake.
- TBPA showed positive correlations with alcohol consumption markers (BMI, GGT) and lipid profiles (ApoA1, HDL-C).
- Negative correlations were observed between TBPA and alpha 2-globulin and gamma-globulin.
Conclusions:
- TBPA is not suitable for discriminating healthy individuals by energy intake or as an index of overnutrition.
- TBPA levels are associated with alcohol consumption and may reflect lipid metabolism and cardiovascular risk factors in healthy adults.