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Cyclodextrins as encapsulation agents for plant bioactive compounds.

Eva Pinho1, Martin Grootveld, Graça Soares

  • 1Institute of Biotechnology and Bioengineering, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal; Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK; Centre for Textile Science and Technology (2C2T), University of Minho, Campus Azurém, 4800-058 Guimarães, Portugal.

Carbohydrate Polymers
|December 5, 2013
PubMed
Summary
This summary is machine-generated.

Cyclodextrins offer a protective encapsulation method for bioactive plant molecules, enhancing their stability and pharmaceutical applications. This review explores their use in preserving plant compounds for improved healing properties.

Keywords:
2,3,6,-trimethyl-β-CD2,6-diethyl-β-CD2,6-dimethyl-β-CD2-hydroxypropyl-α-CD2-hydroxypropyl-β-CD2-hydroxypropyl-γ-CDBioavailabilityCDCM-β-CDCME-β-CDCyclodextrinDE-β-CDDHPDM-β CDDMAFlavonoidsG1-β-CDG2-β-CDGUG-β-CDHAT-β-CDHE-β-CDHP-α-CDHP-β-CDHP-γ-CDICInclusion complexKM-β-CDNMRO-carboxymethyl-O-ethyl-β-CDO-carboxymethyl-β-CDPholyphenolicRM-β-CDROSSBE-β-CDSolubilityTA-β-CDTE-β-CDTM-β-CDTV-β-CDUV-Visacetylated-2,6-dimethyl-β-CDconstant stabilitycyclodextrinsdihydroxypropyl-β-CDglucuronyl-glucosyl-β-CDglycosyl-β-CDhydroxyethyl-β-CDhydroxytrimethyl-ammoniumpropyl-β-CDinclusion complexmaltosyl-β-CDmethyl-β-cyclodextrinnuclear magnetic resonanceper-ο-acetyl-β-CDper-ο-ethyl-β-CDper-ο-valeryl-β-CDrandomly methylated-β-CDreactive oxygen speciessulfate and sulfobutylether β-CDultraviolet-visible light

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Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Natural Product Chemistry
  • Materials Science

Background:

  • Plants contain numerous bioactive molecules (e.g., fiber, vitamins, polyphenols) with therapeutic potential.
  • These plant-derived compounds require protection from environmental degradation to maintain structural integrity and bioactivity.
  • Cyclodextrins, derived from starch, are effective, inexpensive, and safe encapsulation agents.

Purpose of the Study:

  • To review the application of cyclodextrins for encapsulating bioactive plant molecules.
  • To highlight the benefits of cyclodextrin encapsulation in the pharmaceutical field.
  • To emphasize the role of cyclodextrins in enhancing the properties of plant-derived compounds.

Main Methods:

  • Literature review focusing on cyclodextrin encapsulation of plant bioactives.
  • Analysis of studies demonstrating improved stability and bioactivity of encapsulated compounds.
  • Evaluation of cyclodextrins' physical, chemical, and biological property enhancement.

Main Results:

  • Cyclodextrins effectively protect a wide array of bioactive plant molecules.
  • Encapsulation by cyclodextrins improves the stability and bioavailability of these compounds.
  • Cyclodextrins enhance the pharmaceutical utility of plant-derived therapeutic agents.

Conclusions:

  • Cyclodextrins are a promising technology for preserving and delivering bioactive plant molecules.
  • Their use in pharmaceutical applications can lead to more effective and stable therapeutic products.
  • Further research into cyclodextrin-mediated delivery systems for plant compounds is warranted.