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Recrystallization of commercial carbamazepine samples-a strategy to control dissolution variability

Felicia Flicker1, Veronika A Eberle, Gabriele Betz

  • 1Industrial Pharmacy Lab, University of Basel, Mülhauserstrasse 51, Basel 4056, Switzerland. gabriele.betz@unibas.ch.

Pharmaceutics
|December 5, 2013
PubMed
Summary

Recrystallization of carbamazepine (CBZ) with PVP reduced dissolution variability and inhibited dihydrate formation. A subsequent controlled grinding step is crucial for consistent drug release and bioequivalence.

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