Related Experiment Video

Updated: May 5, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

15.4K

[State of kinin regulation and endothelial function in patients with ischaemic stroke]

A Zh Bekbosynov

    Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
    |December 5, 2013
    PubMed

    The study was aimed at assessing the degree of impairments of the kinin mechanisms by the level of antibodies to bradykinin in patients with ischaemic stroke in association with the indices of the vascular endothelium function. We examined people belonging to four various categories, i.e. 30 apparently healthy people (the control group), 30 high-risk patients with degree I-II arterial hypertension, 56 patients with degree II-III arterial hypertension running very high risk for cardiovascular disease, and 35 patients undergoing in-hospital treatment for acute stage of ischaemic stroke. We determined the content of natural antibodies to bradykinin (NABB) and the indices of endothelial function. We revealed alterations in the content of NABB in all groups of patients as compared with the control group. Their degree depended upon the disease and was highest in patients with stroke. Simultaneously we revealed impaired functioning of the vascular endothelium, the key manifestation of which was a pronounced decrease in the endothelium-dependent vasodilation in patients with stroke. Despite different directivity of alterations of certain indices of endothelial function in the groups of patients, we revealed statistically significant correlations of the alterations with the content of NABB.

    More Related Videos

    Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice08:41

    Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

    Published on: December 29, 2016

    11.1K
    Assessing Endothelial Vasodilator Function with the Endo-PAT 200007:46

    Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

    Published on: October 15, 2010

    45.2K

    Related Concept Videos

    Ischemic Stroke ll: Pathophysiology01:15

    Ischemic Stroke ll: Pathophysiology

    An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
    54
    Regulation of Stroke Volume01:27

    Regulation of Stroke Volume

    The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
    Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
    7.3K
    Ischemic Stroke l: Introduction01:15

    Ischemic Stroke l: Introduction

    Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
    44
    Hemorrhagic Stroke ll: Pathophysiology01:29

    Hemorrhagic Stroke ll: Pathophysiology

    A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
    30
    Acute Inflammation II: Local and Systemic Effects01:25

    Acute Inflammation II: Local and Systemic Effects

    Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
    56
    Vascular Spasm01:16

    Vascular Spasm

    The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
    4.9K