Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Triphenylphosphonium compounds preferentially inhibit long-chain fatty acid oxidation in cardiac mitochondria.

Research square·2026

Same author

Insulin plant (Costus igneus) extract alleviates steatosis and adiposity in a murine MASLD model by modulating hepatic lipogenesis and the CD9-CFD immunoregulatory axis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Same author

A novel pharmacological inhibitor of MAP4K4 activity attenuates metabolic dysfunction-associated steatohepatitis.

JHEP reports : innovation in hepatology·2026

Same author

Cardiotropic ligand-guided liposomes for myocardial delivery of atorvastatin in a mouse model of myocardial infarction.

International journal of pharmaceutics·2025

Same author

Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice.

Aging·2025

Same author

Quantum Dot Erythropoietin Bioconjugates Enhance EPO-Receptor Clustering on Transfected Human Embryonic Kidney Cells.

Bioconjugate chemistry·2025

Search research articles

Related Experiment Video

Updated: May 5, 2026

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

Surface engineering of liposomes for stealth behavior.

Okhil K Nag¹, Vibhudutta Awasthi

¹Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA. vawasthi@ouhsc.edu.

|December 5, 2013

Summary

This summary is machine-generated.

Researchers are exploring new materials to improve liposome drug delivery systems. Alternatives to poly(ethylene glycol)-linked phospholipids (PEG-PLs) offer enhanced stability and reduced immune response for better stealth properties.

More Related Videos

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Related Experiment Videos

Last Updated: May 5, 2026

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Area of Science:

Biomaterials Science
Nanotechnology
Pharmaceutical Sciences

Background:

Liposomes are crucial drug delivery vehicles, but conventional formulations face rapid clearance by the mononuclear phagocyte system.
Surface modification with hydrophilic polymers, like poly(ethylene glycol)-linked phospholipids (PEG-PLs), creates 'stealth' liposomes to prolong circulation.
PEG-PLs have limitations including immunogenicity and suboptimal drug loading, prompting research into alternatives.

Purpose of the Study:

To review emerging materials for liposome surface engineering as alternatives to PEG-PLs.
To highlight novel stealth lipopolymers offering improved characteristics over traditional PEG-based systems.
To discuss the advantages of non-phospholipid and PEG-alternative stealth lipopolymers.

Main Methods:

Review of scientific literature on liposome surface modification materials.
Analysis of the properties and applications of PEG-PLs and their alternatives.
Comparison of stealth lipopolymers based on structural versatility, stability, and biological impact.

Main Results:

Poly(ethylene glycol)-linked phospholipids (PEG-PLs) are widely used but exhibit drawbacks like immunogenicity.
Novel stealth lipopolymers utilizing non-phospholipids and PEG alternatives are emerging.
These new materials offer potential benefits such as reduced complement activation and enhanced stability.

Conclusions:

Alternative stealth lipopolymers present a promising avenue for advanced liposome drug delivery.
These novel materials may overcome the limitations associated with PEG-PLs, improving drug targeting and efficacy.
Further research into these materials could lead to more effective and safer liposomal therapeutics.