Related Experiment Video
Updated: May 5, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
10.6K
Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a
Aliki Xochelli1, Christina Kalpadakis, Anne Gardiner
1Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece;
Blood
|December 5, 2013
Summary
Clonal B-cell lymphocytosis of marginal-zone origin (CBL-MZ) is poorly understood but often remains stable. Chromosome 7q deletions were linked to stability, while complex karyotypes indicated progression, suggesting CBL-MZ may be a distinct entity.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- The clinical significance of clonal B-cell lymphocytosis with a marginal-zone origin (CBL-MZ) is not well-defined.
- Existing classifications may not fully encompass these cases.
Purpose of the Study:
- To investigate the biological and clinical characteristics of CBL-MZ.
- To determine factors associated with disease progression.
Main Methods:
- Retrospective analysis of 102 CBL-MZ cases.
- Immunophenotyping, bone marrow biopsy, karyotyping, and immunogenetics were performed.
- Median follow-up of 5 years.
Main Results:
- Most cases (85/102) remained stable; 17 progressed, 15 developing splenomegaly.
- Chromosome 7q deletions were associated with stable disease (Group A).
- Complex karyotypes were more frequent in progressing cases (Group B).
Conclusions:
- CBL-MZ cases are often stable, potentially representing a distinct entity within marginal zone B-cell disorders.
- While CBL-MZ may precede splenic marginal zone lymphoma/small lymphocytic unclassifiable, its distinct clinical course warrants further investigation.
- Karyotypic abnormalities, specifically 7q deletions and complex karyotypes, may aid in predicting disease trajectory.
Related Concept Videos
01:23Cells of the Adaptive Immune Response
6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
01:24B Cell Activation and Differentiation
14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K
01:18Lymphoid Cells and Tissues
3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
01:22T Cell Activation and Clonal Selection
13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K