[Benign clear cell tumor of the lung--a study of immunohistochemistry]

A case of benign clear cell tumor of the lung was investigated immunohistochemically and histochemically. The tumor cells showed a packed proliferation pattern composed of two cell types. The one had polygonal, abundant eosinophilic cytoplasm, and the other had clear cytoplasm. These cells contained glycogen in the cytoplasm, detected by PAS and diastase treatment. Immunohistochemically, the tumor was strongly and diffusely stained by anti-vimentin antibody. And anti-NSE and S-100 protein antibodies were also positive in part. But anit keratin, Factor VIII, desmin, myoglobin and myosin antibodies were entirely negative. These results suggest that this tumor is a special neoplasia originating from neural tissue.