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Updated: May 5, 2026

Electrophysiological Measurements from a Moth Olfactory System
Published on: March 29, 2011
Effects of double-bond configuration on interaction between a moth sex pheromone component and its receptor : A
T Liljefors1, M Engtsson, B S Hansson
1Department of Organic Chemistry 3 Chemical Center, University of Lund, P.O. Box 124, S-221 00, Lund, Sweden.
Abstract:
The dependence of the electrophysiological activity on the change of double-bond configuration of (Z)-5-decenyl acetate, a pheromone component of the turnip moth,Agrotis segetum, and a dienic analog, (E)-2,(Z)-5-decadienyl acetate, have been investigated by single-cell measurements and molecular mechanics calculations (MM2). A previously reported model for the interaction between a moth sex pheromone component and its receptor has been refined. This new model gives an essentially quantitative correlation between the measured activities and the calculated conformational energies for a biologically active conformation defined by the model. Previously obtained structure-activity results for chain-elongated analogs of (Z)-5-decenyl acetate are significantly improved by the refined model. The effect of a change of the double-bond configuration on the substrate-receptor interaction is not additive but depends on the conformational properties of the entire molecule.
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