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Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

Published on: April 16, 2016

A dual enzyme functionalized nanostructured thulium oxide based interface for biomedical application.

Jay Singh¹, Appan Roychoudhury, Manish Srivastava

¹Department of BIN Fusion Technology, Department of Polymer-Nano Science and Technology, Chonbuk National University, Jeonju, Jeonbuk 561-756, Korea. lsh1@jbnu.ac.kr.

|December 5, 2013

Summary

This summary is machine-generated.

Researchers developed a novel thulium oxide (Tm2O3) nanostructure biosensor for efficient total cholesterol detection. This rare earth metal oxide interface offers improved sensing characteristics and rapid, sensitive analysis in human serum samples.

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Last Updated: May 5, 2026

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Published on: April 16, 2016

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

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Biofunctionalization of Magnetic Nanomaterials

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Published on: July 16, 2020

Area of Science:

Electrochemistry
Materials Science
Nanotechnology

Background:

Biosensors are crucial for detecting biomarkers.
Rare earth metal oxides offer unique properties for sensor development.
Nanostructured materials enhance electrode performance.

Purpose of the Study:

To fabricate an efficient biosensor using nanostructured thulium oxide (n-Tm2O3).
To investigate the sensing characteristics of the n-Tm2O3 interface.
To develop a total cholesterol biosensor with improved performance.

Main Methods:

Hydrothermal synthesis of n-Tm2O3 nanorods.
Electrophoretic deposition (EPD) onto indium-tin-oxide (ITO) glass.
Immobilization of cholesterol esterase (ChEt) and cholesterol oxidase (ChOx).
Characterization using XRD, SEM, TEM, XPS, and FTIR.

Main Results:

n-Tm2O3 nanorods enhanced electroactive surface area and electron transfer kinetics.
Fabricated biosensor showed a broad linear range (8-400 mg dL⁻¹).
Achieved a low detection limit (19.78 mg (dL cm⁻²))⁻¹ and high sensitivity (0.9245 μA (mg per dL cm⁻²))⁻¹.
Demonstrated rapid response time (40 s) and negligible interference (<3%) in human serum.

Conclusions:

Nanostructured thulium oxide provides an efficient interface for biosensor fabrication.
The developed biosensor is suitable for sensitive and selective total cholesterol determination.
This work highlights the potential of rare earth metal oxides in electrochemical sensors and bioelectronic devices.