Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Borderline Personality Disorder01:25

Borderline Personality Disorder

1.1K
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
1.1K
Bipolar Disorder01:30

Bipolar Disorder

1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

1.5K
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
1.5K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.3K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.3K
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

771
Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle...
771
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

110
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
110

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flavonoids from <i>Acer okamotoanum</i> Inhibit Adipocyte Differentiation and Promote Lipolysis in the 3T3-L1 Cells.

Molecules (Basel, Switzerland)·2020
Same author

Improvement of digital PCR conditions for direct detection of KRAS mutations.

Journal of clinical laboratory analysis·2020
Same author

Clinical Practice Guideline for Endoscopic Resection of Early Gastrointestinal Cancer.

Clinical endoscopy·2020
Same author

Polymorphisms in Glycolysis-Related Genes Are Associated with Clinical Outcomes of Paclitaxel-Cisplatin Chemotherapy in Non-Small Cell Lung Cancer.

Oncology·2020
Same author

Improved detection of hepatocellular carcinoma by dynamic computed tomography in cirrhotic patients with chronic hepatitis B: A multicenter study.

Journal of gastroenterology and hepatology·2020
Same author

Development and growth of auricular cartilage and muscles: A study using human fetuses.

International journal of pediatric otorhinolaryngology·2020

Related Experiment Video

Updated: May 5, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.7K

Impulsive behavior and recurrent major depression associated with dandy-walker variant.

Ji Hyun Kim1, Tae Ho Kim, Young Chil Choi

  • 1Department of Psychiatry, Konkuk University Chungju Hospital, Konkuk University, Chungju, Republic of Korea.

Psychiatry Investigation
|December 5, 2013
PubMed
Summary

This case study highlights a patient with Dandy-Walker variant experiencing recurrent major depression and impulse control issues. It suggests cerebellar lesions may contribute to these symptoms in major depressive disorder.

Keywords:
AggressionCerebellumDandy-Walker variantDepressionImpulse control

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Na&#239;ve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

13.6K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.6K

Related Experiment Videos

Last Updated: May 5, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.7K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Na&#239;ve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

13.6K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.6K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Dandy-Walker variant is a rare congenital brain malformation.
  • Recurrent major depression and impulse control difficulties are significant psychiatric concerns.
  • The association between Dandy-Walker variant and these specific psychiatric symptoms is not well-established.

Purpose of the Study:

  • To report a unique case of recurrent major depression with impulse control difficulty in a patient with Dandy-Walker variant.
  • To explore the potential link between cerebellar pathology and psychiatric manifestations.

Main Methods:

  • Case report of a 33-year-old male patient.
  • Diagnosis of major depressive disorder and Dandy-Walker variant.
  • Pharmacological treatment with sodium valproate, mirtazapine, and quetiapine.
  • Clinical observation over a three-month hospitalization period.

Main Results:

  • The patient presented with recurrent major depression and impulse control difficulties.
  • Symptoms showed partial reduction with a combination of sodium valproate, mirtazapine, and quetiapine.
  • This is the first reported case linking Dandy-Walker variant with recurrent depression and impulse control issues.

Conclusions:

  • Cerebellar lesions, such as those associated with Dandy-Walker variant, may play a role in the development of recurrent depression with impulse control difficulty.
  • Further research is warranted to investigate the neurobiological underpinnings of this association.