Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

25
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
25
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

20
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

6.3K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
6.3K
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

40
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
40
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

27
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component...
27
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Non-Contiguous Pachymeningeal Dissemination of Isocitrate Dehydrogenase (IDH)-Wildtype Giant Cell Glioblastoma: A Rare Finding During Adjuvant Therapy.

Cureus·2026
Same author

Radiomics for Preoperative Assessment of Pituitary Adenoma Consistency with T2-Weighted MRI: A Multicenter Study.

Journal of neurological surgery. Part B, Skull base·2026
Same author

Iterative Virtual and Physical Simulation for Staged Separation of Total Vertical Craniopagus: The Avatar Patient Approach to Conjoined Twins.

Operative neurosurgery (Hagerstown, Md.)·2026
Same author

The impact of augmented reality on radiation exposure during spine surgery: a systematic review.

Neurosurgical review·2026
Same author

Enhancing Neurosurgical Training: A Comparative Study of Hybrid, Simulator-Based, and Body Donor-Based Dissection Courses.

World neurosurgery·2026
Same author

Deep Learning-Based Videomics for Automatic Segmentation in Endoscopic Endonasal Surgery.

Annali italiani di chirurgia·2026

Related Experiment Video

Updated: May 5, 2026

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
05:51

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat

Published on: June 29, 2021

1.4K

Can neck swelling lead to spinal cord compression?

Emanuele Costi1, Elena Roca, Fabio Spanu

  • 1Emanuele Costi, Elena Roca, Fabio Spanu, Federico Nicolosi, Giovanni Nodari, Marco Fontanella, Pier Paolo Panciani, Department of Neuroscience, Division of Neurosurgery, University of Brescia, 25123 Brescia, Italy.

World Journal of Clinical Cases
|December 5, 2013
PubMed
Summary

A rare case of spinal cord compression from pulmonary sarcomatoid carcinoma metastasis caused significant symptoms. Early diagnosis is crucial for better outcomes in this unusual presentation.

Keywords:
CarcinosarcomaPulmonary sarcomatoid carcinomaSpinal cord compressionSpine surgeryTetraparesis

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

8.3K
Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
04:33

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

1.1K

Related Experiment Videos

Last Updated: May 5, 2026

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
05:51

A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat

Published on: June 29, 2021

1.4K
Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

8.3K
Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review
04:33

Spinal Hernia Repair and Cauda Equina Repositioning After Lumbar Decompression under Three-Dimensional Microscopy: A Case Report and Literature Review

Published on: November 8, 2024

1.1K

Area of Science:

  • Oncology
  • Neurology
  • Radiology

Background:

  • Pulmonary sarcomatoid carcinoma is a rare subtype of non-small cell lung cancer.
  • Spinal cord compression (SCC) can result from metastatic disease, but cervical invasion by this specific tumor type is unprecedented.

Observation:

  • A 59-year-old male with a history of pulmonary carcinosarcoma presented with progressive neck swelling and severe tetraparesis.
  • Cervical spine CT revealed a large mass (11x27x17 cm) causing spinal cord compression from the occiput to C7.

Findings:

  • The patient underwent emergency spinal cord decompression, resulting in minimal neurological improvement.
  • The unusual clinical presentation led to a delayed diagnosis and treatment, contributing to the poor outcome.

Implications:

  • This case highlights the importance of considering rare metastatic patterns in oncology.
  • Recognizing unusual presentations of spinal cord compression is critical for timely intervention and management.
  • Further research into the metastatic behavior of pulmonary sarcomatoid carcinoma may improve diagnostic and therapeutic strategies.