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Related Concept Videos

External Female Genitals01:15

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The vulva encompasses the external structures of the female reproductive system. At the forefront is the monpubis, a cushion of fatty tissue atop the pubic bone. Once puberty sets in, this area typically grows hair. Extending from just behind the mons pubis are the labia majora (labia = 'lips'; majora = 'larger'), which are larger skin fs olds coated with hair. Nestled within are the labia minora (labia = 'lips'; minora = 'smaller'), which are thinner, more...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Classification of Epithelial Tissues: Glandular Epithelium01:20

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
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After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
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Related Experiment Video

Updated: May 5, 2026

Primary Culture of Human Vestibular Schwannomas
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Vulvar granular cell tumor.

Michel E Rivlin1, G Rodney Meeks, Mohamed A Ghafar

  • 1Michel E Rivlin, G Rodney Meeks, Mohamed A Ghafar, Jack R Lewin, Departments of Obstetrics, Gynecology and Pathology, University of Mississippi Medical Center, Jackson, MS 39216, United States.

World Journal of Clinical Cases
|December 5, 2013
PubMed
Summary
This summary is machine-generated.

Granular cell tumors, often benign soft tissue neoplasms, can occur in the vulva. Intraoperative frozen section analysis is recommended for positive margins to prevent recurrence.

Keywords:
Granular cell tumorVulvar neoplasmVulvar tumor

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Granular cell tumors (GCTs) are rare soft tissue neoplasms of neural origin, predominantly affecting females aged 40-50.
  • While GCTs can occur anywhere, 15% are found in the vulva, typically presenting as asymptomatic masses.
  • The majority of vulvar GCTs (98%) are benign, with only 2% exhibiting malignant characteristics.

Observation:

  • A case report details a woman with a vulvar granular cell tumor diagnosed via biopsy.
  • The initial excision revealed focal extension to the resection margin on microscopy.
  • Re-excision was declined by the patient, despite the known risk of microscopic tumor extension beyond macroscopic limits.

Findings:

  • Microscopic examination is crucial for GCT diagnosis, with immunohistochemistry offering supplementary confirmation.
  • Positive resection margins in GCT excision are associated with higher recurrence rates (20%) compared to clear margins (2%-8%).

Implications:

  • Intraoperative frozen section analysis for margin assessment during GCT excision is advisable to ensure complete tumor removal.
  • Prompt re-excision with frozen section control is indicated if recurrence occurs.
  • This approach can potentially reduce GCT recurrence rates and improve patient outcomes.