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Related Experiment Videos

Dosage range study of morphine sulfate controlled-release.

H D Homesley, C E Welander, H B Muss

    American Journal of Clinical Oncology
    |October 1, 1986
    PubMed
    Summary

    Morphine sulfate controlled-release (MSCR) effectively manages cancer pain, offering preferred relief and fewer side effects compared to previous narcotics. This study confirms MSCR

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    Area of Science:

    • Oncology
    • Pain Management
    • Pharmacology

    Background:

    • Cancer pain management often requires effective and safe analgesics.
    • Previous narcotic analgesia may have limitations in efficacy or side effect profiles.
    • Morphine sulfate immediate-release (MSIR) is used for around-the-clock (ATC) dosing.

    Purpose of the Study:

    • To evaluate the efficacy and side effects of morphine sulfate controlled-release (MSCR).
    • To assess MSCR in cancer patients previously treated with narcotic analgesia.
    • To establish appropriate dosage regimens for MSCR.

    Main Methods:

    • Conversion of 30 patients from prior analgesics to MSIR ATC 4-h dosing.
    • Subsequent conversion to MSCR, establishing a 12-h schedule for most.

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  • Maintenance on MSCR for 4 weeks, with 24 patients completing the study.

    • Main Results:

    • Patients preferred MSCR for analgesic relief over previous regimens.
    • Half of the patients experienced fewer side effects with MSCR compared to prestudy narcotics.
    • No patients reported increased side effects with MSCR.

    Conclusions:

    • Morphine sulfate controlled-release (MSCR) is effective and safe for prolonged cancer pain relief.
    • MSCR offers a preferred alternative with a favorable side effect profile.
    • Appropriate dosage is key for optimal outcomes with MSCR in cancer pain management.