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Related Concept Videos

Types of RNA01:20

Types of RNA

13.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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RNA Structure01:23

RNA Structure

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Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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Tackling structures of long noncoding RNAs.

Irina V Novikova1, Scott P Hennelly, Karissa Y Sanbonmatsu

  • 1Los Alamos National Laboratory, Los Alamos, NM 87545, USA. kys@lanl.gov.

International Journal of Molecular Sciences
|December 6, 2013
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are crucial gene regulators, but their structures are poorly understood. Chemical probing offers a versatile method to investigate lncRNA structures, advancing our knowledge of their functions.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • RNAs function as catalysts and regulators in gene expression.
  • Long non-coding RNAs (lncRNAs) are a newly identified class implicated in various biological processes.
  • lncRNAs are structurally versatile but remain the least characterized RNA class.

Purpose of the Study:

  • To review methodologies for RNA structure determination.
  • To emphasize the application of these methods to lncRNAs.
  • To highlight chemical probing as a key technique for lncRNA structural analysis.

Main Methods:

  • Review of common RNA structure determination techniques.
  • Focus on chemical probing methods and their adaptability.
  • Integration of chemical probing with high-throughput sequencing.

Main Results:

  • Chemical probing is a versatile tool for studying lncRNA structure, irrespective of size, quantity, or heterogeneity.
  • Probing methods can be adapted for in vitro and in vivo analyses.
  • Advancements include new reagents, library preparation protocols, and prediction software.

Conclusions:

  • Chemical probing is indispensable for characterizing lncRNA structures due to its flexibility.
  • Ongoing developments enhance the utility of chemical probing for lncRNAs.
  • Improved structural insights will advance understanding of lncRNA roles in evolution, development, and disease.